We have a database of more than two thousand treating physicians who are proactive in out-patient clinics, private and regional medical centers that are not accredited to conduct clinical trials. We have reached out to them and executed confidentiality and referral site agreements that allow them to refer patients to our clinical trial sites. Every time we initiate a clinical trial we inform them of inclusion and exclusion criteria and encourage them to refer their patients to trial locations that are most proximal to them. See below a real-life example of improvement in enrollment of in an orphan disease trial with the addition of Cromos Pharma’s referral site network.
Case study: Cromos Pharma was approached to conduct a clinical trial in an orphan disease. The study was already ongoing in 11 countries and the recruitment was seriously lagging behind. We performed a feasibility study in our region and realized that even our highest-recruiting sites would have difficulties with recruitment. Upon receiving the approval from the sponsor, we engaged our referral site network where for a small fee we offered outlying physicians to refer their patients to our clinical trial sites. We had subsequently opened 18 sites in 4 countries and engaged with 72 referral sites. In less than 9 months of study conduct we outperformed the recruitment in all other countries. Analyzing the recruitment data we found that 40% of recruited patients came from our referral network.